Celeste Solum
Researchers Testing Aerosolized Drug Delivery System
To the Brain
by Celeste . February 07, 2018
Aerosolized nanotechnology holds the key to a non-invasive drug delivery system to the brain. This novel approach is based upon science and engineering that allow the synthesis of nano-particles, as a drug carrier.
Nano-particles are deposited into the upper regions of the nasal cavity where they permeate the nasal epithelium and then finally are transported by the olfactory nerves to the brain. Intranasal deliver is the fastest way to deliver ‘therapeutic agents’ the central nervous system and the brain.
Researchers at Washington University in St. Louis researchers investigated a proof of concept study to demonstrate that an aerosol consisting of gold nanoparticles of controlled size, shape, and surface charge can be delivered to the brains of locusts.
These aerosols can reach the brain within 30 minutes after the introduction of the nanoparticle aerosol without noticeable adverse changes in the electrophysiological response.
Up until this time efforts to deliver substances to the brain through various methods were either invasive, caused damage, or failed at crossing the blood-brain barrier.
Testing at this time is being conducted on locusts with researchers looking for future application for things such as treating concussions.
Aerosol-based, non-invasive drug delivery reduces the inflammatory cascade that occurs transport mechanisms, viable pharmaceutical has the potential to rapidly and effective. Once the aerosolized drug delivery system is perfected it will be the perfect conduit to over things such as vaccination resistance and drug deliveries to large masses of people.
Sources:https://www.hdiac.org/system/files/HDIAC%20Journal_Volume%204_Issue_4.pdf
